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Home - Products - MAPK/ERK Signaling - Ras - KRAS inhibitor-9

KRAS inhibitor-9

CAS No. 300809-71-6

KRAS inhibitor-9( DUN09716 )

Catalog No. M22747 CAS No. 300809-71-6

KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KRAS inhibitor-9
  • Note
    Research use only, not for human use.
  • Brief Description
    KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS.?
  • Description
    KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS.??KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells
  • Synonyms
    DUN09716
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    KRAS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    300809-71-6
  • Formula Weight
    292.8
  • Molecular Formula
    C13H9ClN2S2?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:230 mg/mL?(785.49 mM;?Need ultrasonic)
  • SMILES
    Nc1ccc(Sc2nc3ccccc3s2)c(Cl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xie C, et al. Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Front Pharmacol. 2017;8:823. Published 2017 Nov 14.
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